منابع مشابه
Mitochondrial Rejuvenation After Induced Pluripotency
BACKGROUND As stem cells of the early embryo mature and differentiate into all tissues, the mitochondrial complement undergoes dramatic functional improvement. Mitochondrial activity is low to minimize generation of DNA-damaging reactive oxygen species during pre-implantation development and increases following implantation and differentiation to meet higher metabolic demands. It has recently b...
متن کاملExpression of Spermatogonial and Pluripotency Markers in Spermatogonial Stem Cells after Treatment with Different Culture Factors
Background: As condition and component of culture determine fate map of spermatogonial stem cells (SSCs), the aim of this study was to evaluate of growth factors GDNF, LIF and RA on proliferation and differentiation of SSC. Materials and Methods: SSCs were cultured in two groups: The first group GDNF and LIF and the second group RA. The number of clumps and colony formation was monitored dur...
متن کاملCapturing Pluripotency
In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-r...
متن کاملStance relativism: empiricism versus metaphysics The Empirical Stance
In The empirical stance, Bas van Fraassen argues for a reconceptualization of empiricism, and a rejection of its traditional rival, speculative metaphysics, as part of a larger and provocative study in epistemology. Central to his account is the notion of voluntarism in epistemology, and a concomitant understanding of the nature of rationality. In this paper I give a critical assessment of thes...
متن کاملBeyond the Guidelines Stance
SEE PAGE 166 F ibrinolysis remains a cornerstone for the treatment of ST-segment elevation myocardial infarction (STEMI) when primary percutaneous coronary intervention (PCI) is not readily available. Its administration in a pre-hospital setting increases the proportion of patients undergoing rapid reperfusion with resultant improved outcomes compared with in-hospital administration (1). The lo...
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ژورنال
عنوان ژورنال: Nature Reports Stem Cells
سال: 2008
ISSN: 1754-8705
DOI: 10.1038/stemcells.2008.25